Physics of Proteins
Jayanth R. Banavar1 and Amos Maritan2
1Department of Physics, The Pennsylvania State University, University Park,
Pennsylvania 16802; email: jayanth@phys.psu.edu
2INFM and Dipartimento di Fisica ‘G. Galilei’, Universit`a di Padova, 35131 Padova,
Key Words
tube, geometry, amyloid, marginally compact phase, symmetry
Abstract
Globular proteins are a key component of the network of life. Over
many decades much experimental data on proteins have been gathered,
yet theoretical progress has been somewhat limited.We show
that the results accumulated over the years inexorably lead to a unified
framework for understanding proteins. The framework predicts
the existence of a fixed menu of folds determined by geometry, clarifies
the role of the amino acid sequence in selecting the native-state
structure from this menu, and explains the propensity for amyloid
formation. The experimental data and the new approach reveal an
astonishing simplicity underlying the protein problem.
Contents
INTRODUCTION. . . . . . . . . . . . . . . . . 262
EXPERIMENTAL RESULTS . . . . . . 263
Common Character of Proteins . . . 263
THEORETICAL DEDUCTIONS. . 263
Evolution and Protein
Interactions . . . . . . . . . . . . . . . . . . . 263
Stability, Sensitivity, Diversity, and
Dynamical Accessibility . . . . . . . . 264
Familiar Phases of Matter . . . . . . . . . 264
Chain Molecules . . . . . . . . . . . . . . . . . 264
Garden Hoses and Tubes . . . . . . . . . 265
Marginally Compact Phase
of a Flexible Tube . . . . . . . . . . . . . 266
Structures of Short Tubes in the
Marginally Compact Phase . . . . 266
Validation of the Hypothesis . . . . . . 268
CONSEQUENCES AND
PREDICTIONS. . . . . . . . . . . . . . . . . 271
Free-Energy Landscape. . . . . . . . . . . 271
Role of Amino Acid Sequence . . . . . 272
Evolution and Natural Selection . . 274
Amyloid Formation. . . . . . . . . . . . . . . 274
Nanoscience and Supramolecular
Chemistry . . . . . . . . . . . . . . . . . . . . 274
SUMMARY. . . . . . . . . . . . . . . . . . . . . . . . . 275
全文地址：
http://arjournals.annualreviews.org/doi/full/10.1146/annurev.biophys.36.040306.132808
如不能打开全文，或需要pdf全文的朋友可以回复留下E-mail.
其他与蛋白质操作过程中的注意事项相关的日志：（Redondo推荐）
1. 如何避免蛋白发生聚集？
2. 使用Ni亲和层析柱纯化蛋白时需要注意的事项
3. 蛋白质操作过程中需要注意的问题
4. 关于蛋白稳定性需要考虑的几个因素
5. 蛋白表达与纯化总结PPT
6. 收藏：沉淀蛋白方法
7. 蛋白样品制备中需要注意的问题
